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Hashimotos and dose of I-131 radiation necessary for ablation (for thyroid cancer)



Hello,
I have been reading about thow the thyroid gland functions.
I want to know what influences iodine uptake by my glands, when I get
radiation tratement for my thyroid cancer.

I have a few questions: logical guesses, even if you dont know for
sure,are appreciated

these are facts as I know them:

1. Enzyme TPO (thyroid peroxidase) acts as a catalyst to bind iodine
and thyroglobulin to get T3 and T4 eventually. This is called
"iodination of thyroglobulin" and is how the iodine gets into the
thyroid gland cells in the first place.

2.  TPOAb(thyroidperoxidase antibody)/antimicrosomal antibodies act
against TPO enzyme.

3. If there is less TPO enzyme, less iodine is taken up by thyroid
cells.

4. Patients with TPOAb antibodies (all things being equal) will have a
RELATIVELY less avid iodine absorption, because of the reduced action
of TPO.

So far is this logical and right ? does anybody have any pointers
relating to hashimotos and radio iodine uptake ?

Anita
Hashimotos- May 2003
Pap Thyca- July 2003



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