Zinc

Exp Mol Pathol. 2003 Dec;75(3):265-76.  Related Articles, Links  


Oxidative stress, toxic hepatitis, and antioxidants with particular emphasis on
zinc.

Stehbens WE.

Department of Pathology and Molecular Medicine, Wellington School of Medicine
and Health Sciences, P.O. Box 7343, Wellington South, New Zealand

Hepatic metabolism of biological toxins, industrial poisons, and medicinal
agents involves disturbed hepatic cell biochemistry with augmented generation
of reactive oxygen species and free radicals and redox imbalance with secondary
damage to proteins, nucleic acids, lipids, and carbohydrates. The xenobiotic
hepatotoxicity ranging from a subclinical anicteric state to severe
necroinflammatory hepatitis (acute, recurrent or chronic) and cirrhosis depends
on the nature, dosage, and duration of exposure to the xenobiotic, the
antioxidant defence, and concomitant exposure to other diseases or xenobiotics.
Experimental and clinical studies suggest that xenobiotic hepatotoxicity with
variable depletion of antioxidants can be avoided or ameliorated by
administration of an unusually high dosage of zinc or by a combination of
antioxidants above normal daily requirements. Therefore reassessment of optimal
prophylactic and therapeutic nutritional requirements of antioxidants
(particularly zinc) to defend humans against xenobiotic induced oxidative
stress is advocated.

PMID: 14611818 [PubMed - in process] 

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