Re: Fortune Magazine Story on NSAIDS, Statins, Aging

Tue, 28 Oct 2003 09:59:18 GMT in article
<[EMAIL PROTECTED]> Matti Narkia
<[EMAIL PROTECTED]> wrote:

> Some herbal extracts also inhibit 5-LOX [30-39].
>These include aethiopinone, silymarin (silybin, silibinin) and boswellia
>(boswellic acids). There are even herbal dual inhibitors ginger for example
>[40].
>
>
>References:
>
<snip>
>
>Herbal dual 5-LOX and COX-2 inhibitors
>--------------------------------------
>
>Ginger
>......
>
>40:  Kiuchi F, Iwakami S, Shibuya M, Hanaoka F, Sankawa U. 
> Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and
>diarylheptanoids.
>Chem Pharm Bull (Tokyo). 1992 Feb;40(2):387-91. 
>PMID: 1606634 [PubMed - indexed for MEDLINE]
><http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1606634&dopt=Abstract>

Saw palmetto (Serenoa repens) extract, which is used in benign prostatic
hypertrophy, seems to be also dual cyclooxygenase and 5-lipoxygenase
inhibitor:

Breu W, Hagenlocher M, Redl K, Tittel G, Stadler F, Wagner H. 
 [Anti-inflammatory activity of sabal fruit extracts prepared with
supercritical carbon dioxide. In vitro antagonists of cyclooxygenase and
5-lipoxygenase metabolism]
Arzneimittelforschung. 1992 Apr;42(4):547-51. German. 
PMID: 1642680 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1642680&dopt=Abstract>

Paubert-Braquet M, Mencia Huerta JM, Cousse H, Braquet P. 
 Effect of the lipidic lipidosterolic extract of Serenoa repens (Permixon)
on the ionophore A23187-stimulated production of leukotriene B4 (LTB4) from
human polymorphonuclear neutrophils.
Prostaglandins Leukot Essent Fatty Acids. 1997 Sep;57(3):299-304. 
PMID: 9384520 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9384520&dopt=Abstract>


-- 
Matti Narkia