Re: New method ruote for 2,5-Dimethoxynitrostyrene

Steve Turner <[EMAIL PROTECTED]> wrote in message news:<[EMAIL PROTECTED]>...
> Chris F <[EMAIL PROTECTED]> wrote:
> 
> 
> >Hey all, I have not posted in here for a wile but I have been wondering, I
> >finally found a interesting route to the nitrostyrene. The procedure looks
> >accurate enough, But sadly that ratios they are using are to small, In
> >theory the ratio or mmol can up scaled up right? I was thinking about it and
> >it would be possible but that factors will change,? Heat length et cetera et
> >cetera, Can any one give me some insight on the possibilities of scaling the
> >procedure up, Of course this would all be theoretical I just want to find
> >out if its at all possible to scale up with ease,
> 
> 
> Planning to make mescaline?
> 
> 
> Real address contains worldnet instead of spamnet

No, sure he wants to make 2,5-Dimethoxyethylamine, not
3,4,5-Trimethoxyethylamine (= Mescaline). Or with a following
bromination, this leads the entry to make 2C-B, which is
4-bromo-2,5-dimethoxyethylamine. That´s really old stuff. Please spare
this forum from those already well known, boring reactions. There are
enough other "forums" where the synthesis is already given.
But to speak chemical: The condensation between donor-substituted
(2,5-dimethoxy) benzaldehydes and CH-acidic nitromethane might cause
some problems in upscaling. The reason is, that the condensation takes
place not with the same ease, when acceptor-substitued benzaldehydes
are used, due to electronical reasons. Also there must be considered
the small gap between the CH-acidity and the nucleophilic character.
Thus this reaction takes only place with good results, when there is
found the "right" base in combination with the CH-acidity. Also the
formed nitrostyrene is very sensitive to polymerisation, that´s only a
question of duration, basicitiy of the base and temperature of the
reaction medium.
-- 
Paul J. Franklin(moderator - sci.chem.organic.synthesis) 
http://organicworldwide.net/sci.chem.organic.synthesis
Georgia State University <[EMAIL PROTECTED]>
Atlanta, GA