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Hi, I need a procedure to react indole with carbonyl chloride to give 3-substituted indole. I know that this can be done using Grignard reagent to abstract hydrogen to activate indole ring or just by a simple reaction of indole with a chloride. I want to avoid Grignard reagent and thus I found such references: J. Med. Chem. 33; 2; 1990; 543-552 J. Med. Chem. 33; 2; 1990; 755-758 I have the journal in my library but the particular issue is missing. Has snybody read it or know similar procedure? Please advise -- Witek http://www.trimen.pl/witek/ -- Paul J. Franklin(moderator - sci.chem.organic.synthesis) http://organicworldwide.net/sci.chem.organic.synthesis Georgia State University <[EMAIL PROTECTED]> Atlanta, GA
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