Doing a comic book cover by hand

While I've noticed that many comic book covers these days are done by
computer with programs like Photoshop and Illustrator, I've heard that
some still do the covers the old fashioned way with pencils, pens, and
some sort of color medium.  Can anyone advise me on a suitable way to
create a comic book cover using a traditional coloring medium as
opposed to the computer?  I've heard some use markers, colored
pencils, or colored inks, but I can't confirm that.