Re: Insulin Action Peak Time Estimate

Jim Dumas wrote:

> So my rule of thumb for estimating peak insulin action, from a GI tract
> post-absorptive BG profile, is the point where BG falls through 150 mg/dl
> (8.3 mmol/l).  The "in the neighborhood" is similar to complex variable
> theory for a point on the complex plane.

There are other assumptions in this estimate.  You must dose correctly to 
achieve euglycemia as the dose wanes.  This is difficult without some 
computer model.  But if you dose low and never pass through 150 mg/dl, then 
you can't use this rule as it stands.  But you could probably scale this as 
150/90 since my personal target is 90 mg/dl.

As an example, let's say I under dosed and it waned with a nadir of 200 
mg/dl.  Then I could estimate the insulin action peak was in the 
neighborhood of 150*200/90=333 mg/dl.  So the dose had its peak activity as 
my BG fell through 333 mg/dl.

Food for thought,
-- 
Jim Dumas
T1 4/86, background retinopathy, rarely hypoglycemic: <1/mo.
lispro+R+U+NPH daily, moderate exercise, typically <6% HbA1c