Electron microscopy showed iron within synovial cells

Arthritis Rheum 1981 May;24(5):706-10



Clearance of calcium pyrophosphate dihydrate crystals in vivo. III. Effects of
synovial hemosiderosis.

McCarty DJ, Palmer DW, Garancis JC
Synthetic triclinic calcium pyrophosphate dihydrate crystals, uniformly labeled
with 85Sr and 45Ca, were injected into the knee joints of 2 normal adult
rabbits and 2 rabbits previously injected repeatedly with autologous blood. The
"half clearance time" of the injected crystal mass was 20.4 and 19 days from
control joints, nearly identical to previously reported values in 6 rabbits
(19.1 +/- 1.4), and 28.8 and 34 days from the joints injected with blood, a
significant difference (P less than 0.05). Iron stains showed hemosiderin
granules in the superficial synovium in these joints. Electron microscopy
showed crystals with a molar calcium/phosphorus ratio of 1.0 and particles
containing iron within synovial cells. We hypothesize that the decreased
clearance rate from hemosiderotic synovium is due to inhibition of one or more
intracellular pyrophosphatases by iron.

PMID: 6263291, UI: 81207376


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