Eliminating the excess iron(III) in living organisms

J Inorg Biochem. 2002 Apr 28;89(3-4):212-8.  Related Articles, Links  

  
Aqueous and solid complexes of iron(III) with hyaluronic acid. Potentiometric
titrations and infrared spectroscopy studies.

Merce AL, Marques Carrera LC, Santos Romanholi LK, Lobo Recio MA.

Departamento de Quimica, Universidade Federal do Parana, CP 19081, Centro
Politecnico, Curitiba, 81531-990, Brazil. [EMAIL PROTECTED]

The coordination of iron(III) ion to hyaluronic acid (Hyal) in aqueous
solutions and solid state was accomplished by potentiometric titrations and
infrared spectroscopy. The potentiometric titration studies provided the
binding constants for the complexes found in the systems and the speciation of
these species according to the variation of pH values. The complexes found
presented a complexing ability through both the chelating moieties of Hyal (via
the N-glucosamine and D-glucoronic acid), showing no special preference for
either one while in solid state, but when in aqueous solution the complexation
via the N-glucosamine moiety was the preferred, forming two complexed species,
ML and ML(2) (log K(ML)=8.2 and log K(ML2)=7.9). The presence of a mu-oxo
complex via the D-glucoronic acid was also detected in both aqueous (log K=6.7)
and solid states via the N-glucosamine and D-glucoronic acid simultaneously
linked to two Hyal chains. A structure for this latter complex was suggested.
The results indicated that these complexes could be used in eliminating the
excess iron(III) in living organisms.

PMID: 12062125 [PubMed - indexed for MEDLINE] 

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